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New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems

Lookup NU author(s): Dr Agnieszka Bronowska

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a "universal"catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis.

Publication metadata

Author(s): Duchemin N, Aubert S, De Souza JV, Bethge L, Vonhoff S, Bronowska AK, Smietana M, Arseniyadis S

Publication type: Article

Publication status: Published

Journal: Journal of the American Chemical Society

Year: 2022

Volume: 2

Issue: 8

Pages: 1910-1917

Print publication date: 22/08/2022

Online publication date: 02/08/2022

Acceptance date: 22/07/2022

Date deposited: 07/10/2022

ISSN (print): 0002-7863

ISSN (electronic): 1520-5126

Publisher: American Chemical Society

URL: https://doi.org/10.1021/jacsau.2c00271

DOI: 10.1021/jacsau.2c00271

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