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Lookup NU author(s): Professor Moein MoghimiORCiD, Hajira -
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The Authors. The contribution of the complement system to non-specific host defence and maintenance of homeostasis is well appreciated. Many particulate systems trigger complement activation but the underlying mechanisms are still poorly understood. Activation of the complement cascade could lead to particle opsonisation by the cleavage products of the third complement protein and might promote inflammatory reactions. Antibody binding in a controlled manner and/or sensing of particles by the complement pattern-recognition molecules such as C1q and mannose-binding lectin can trigger complement activation. Particle curvature and spacing arrangement/periodicity of surface functional groups/ligands are two important parameters that modulate complement responses through multivalent engagement with and conformational regulation of surface-bound antibodies and complement pattern-recognition molecules. Thus, a better fundamental understanding of nanometer- and angstrom-scale parameters that modulate particle interaction with antibodies and complement proteins could portend new possibilities for engineering of particulate drug carriers and biomedical platforms with tuneable complement responses and is discussed here.
Author(s): Moghimi SM, Haroon HB, Yaghmur A, Simberg D, Trohopoulos PN
Publication type: Article
Publication status: Published
Journal: Journal of Controlled Release
Year: 2022
Volume: 351
Pages: 432-443
Print publication date: 01/11/2022
Online publication date: 27/09/2022
Acceptance date: 18/08/2022
Date deposited: 12/10/2022
ISSN (print): 0168-3659
ISSN (electronic): 1873-4995
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.jconrel.2022.09.039
DOI: 10.1016/j.jconrel.2022.09.039
PubMed id: 36152807
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