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Lookup NU author(s): Dr Dexter CanoyORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021, The Author(s).Blood pressure and bone metabolism appear to share commonalities in their physiologic regulation. Specific antihypertensive drug classes may also influence bone mineral density. However, current evidence from existing observational studies and randomised trials is insufficient to establish causal associations for blood pressure and use of blood pressure–lowering drugs with bone health outcomes, particularly with the risks of osteoporosis and fractures. The availability and access to relevant large-scale biomedical data sources as well as developments in study designs and analytical approaches provide opportunities to examine the nature of the association between blood pressure and bone health more reliably and in greater detail than has ever been possible. It is unlikely that a single source of data or study design can provide a definitive answer. However, with appropriate considerations of the strengths and limitations of the different data sources and analytical techniques, we should be able to advance our understanding of the role of raised blood pressure and its drug treatment on the risks of low bone mineral density and fractures. As elevated blood pressure is highly prevalent and blood pressure–lowering drugs are widely prescribed, even small effects of these exposures on bone health outcomes could be important at a population level.
Author(s): Canoy D, Harvey NC, Prieto-Alhambra D, Cooper C, Meyer HE, Asvold BO, Nazarzadeh M, Rahimi K
Publication type: Article
Publication status: Published
Journal: Osteoporosis International
Year: 2022
Volume: 33
Issue: 2
Pages: 315-326
Print publication date: 01/02/2022
Online publication date: 13/10/2021
Acceptance date: 01/10/2021
Date deposited: 24/11/2022
ISSN (print): 0937-941X
ISSN (electronic): 1433-2965
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s00198-021-06190-0
DOI: 10.1007/s00198-021-06190-0
PubMed id: 34642814
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