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Lookup NU author(s): Professor David GrahamORCiD, Dr Josh Bunce
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
Author(s): Munk P, Brinch C, Møller FD, Petersen TN, Hendriksen RS, Seyfarth AM, Kjeldgaard JS, Svendsen CA, vanBunnik B, Berglund F, Sewage Surveillance Consortium, Larsson DGJ, Koopmans M, Woolhouse M, Aarestrup M, Bunce JT
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2022
Volume: 13
Print publication date: 01/12/2022
Online publication date: 01/12/2022
Acceptance date: 20/10/2022
Date deposited: 06/12/2022
ISSN (electronic): 2041-1723
Publisher: Nature Publishing
URL: https://doi.org/10.1038/s41467-022-34312-7
DOI: 10.1038/s41467-022-34312-7
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