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Lookup NU author(s): Niall Wilson, Dr Tetsushi Kataura, Dr Viktor Korolchuk
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The AuthorsAutophagy is an intracellular degradation pathway that recycles subcellular components to maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy metabolism and serves as a substrate for a series of NAD+-consuming enzymes (NADases), including PARPs and SIRTs. Declining levels of autophagic activity and NAD represent features of cellular ageing, and consequently enhancing either significantly extends health/lifespan in animals and normalises metabolic activity in cells. Mechanistically, it has been shown that NADases can directly regulate autophagy and mitochondrial quality control. Conversely, autophagy has been shown to preserve NAD levels by modulating cellular stress. In this review we highlight the mechanisms underlying this bidirectional relationship between NAD and autophagy, and the potential therapeutic targets it provides for combatting age-related disease and promoting longevity.
Author(s): Wilson N, Kataura T, Korsgen ME, Sun C, Sarkar S, Korolchuk VI
Publication type: Review
Publication status: Published
Journal: Trends in Cell Biology
Year: 2023
Volume: 33
Issue: 9
Pages: 788-802
Print publication date: 01/09/2023
Online publication date: 04/03/2023
Acceptance date: 02/04/2022
ISSN (print): 0962-8924
ISSN (electronic): 1879-3088
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.tcb.2023.02.004
DOI: 10.1016/j.tcb.2023.02.004
PubMed id: 36878731
