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Lookup NU author(s): Sean Hockney, Dr Deepali Pal
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia-niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leukaemia cells, this poses as a key clinical challenge that hinders management of this disease. Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets. Additionally, we discuss microenvironment-driven treatment resistance and relapse, and elaborate the role of CDH2-mediated cancer cell protection from chemotherapy. Finally, we review emerging therapeutic approaches that directly target CDH2-mediated adhesive interactions between the BM cells and leukaemia cells.
Author(s): Parker J, Hockney S, Blaschuk OW, Pal D
Publication type: Review
Publication status: Published
Journal: Expert Reviews in Molecular Medicine
Year: 2023
Volume: 25
Online publication date: 03/05/2023
Acceptance date: 01/05/2023
ISSN (electronic): 1462-3994
Publisher: NLM (Medline)
URL: https://doi.org/10.1017/erm.2023.13
DOI: 10.1017/erm.2023.13
PubMed id: 37132370
