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Moderate doses of dietary nitrate elicit greater effects on blood pressure and endothelial function than a high dose: A 13-week pilot study

Lookup NU author(s): Dr Oliver Shannon, Dr Gerry O'BrienORCiD, Dilara Olgacer, William Fostier, Professor John Mathers, Dr Mario Siervo

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Abstract

Background & aimsFew studies have explored the prolonged effects of dietary nitrate on vascular health. This pilot study tested the effects of prolonged consumption (13 weeks) of a range of doses of dietary nitrate (NO₃⁻), provided as beetroot juice (BJ), on blood pressure (BP) and endothelial function in overweight and obese older participants.Methods and resultsSixty-two overweight or obese older participants (60–75 years) were randomized to the following interventions: (1) high NO₃⁻ (2) medium NO₃⁻, (3) low NO₃⁻, or (4) placebo. Resting clinic and home BP were measured pre- and post-intervention. Laser Doppler iontophoresis was used to quantify changes in endothelial-dependent and independent microvascular blood flow.ResultsThis pilot study showed that medium and low doses of NO₃⁻ were more effective in lowering resting-clinic SBP (P = 0.04 and, P = 0.03, respectively) than was PL. The lower doses of NO₃⁻ also resulted in significant increases in microvascular perfusion (medium, P = 0.02; low, P = 0.002) relative to baseline values.ConclusionThese findings indicate that supplementation with medium and low, but not high, doses of NO₃⁻ for 13 weeks had positive effects on BP and endothelial function in older overweight and obese adults. These findings require confirmation in larger studies

Publication metadata

Author(s): Babateen AM, Shannon OM, O'Brien GM, Olgacer D, Koehl C, Fostier W, Mathers JC, Siervo M

Publication type: Article

Publication status: Published

Journal: Nutrition, Metabolism and Cardiovascular Diseases

Year: 2023

Volume: 33

Issue: 6

Pages: 1263-1267

Print publication date: 13/03/2023

Online publication date: 02/03/2023

Acceptance date: 27/02/2023

ISSN (print): 0939-4753

ISSN (electronic): 1590-3729

Publisher: Elsevier

URL: https://doi.org/10.1016/j.numecd.2023.02.024

DOI: 10.1016/j.numecd.2023.02.024

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