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Interbacterial competition mediated by the type VIIb secretion system

Lookup NU author(s): Ellie Boardman, Professor Tracy Palmer FRS FRSE FMedSciORCiD, Dr Felicity AlcockORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2023 The Authors. Successful occupancy of a given niche requires the colonising bacteria to interact extensively with the biotic and abiotic environment, including other resident microbes. Bacteria have evolved a range of protein secretion machines for this purpose with eleven such systems identified to date. The type VIIb secretion system (T7SSb) is utilised by Bacillota to secrete a range of protein substrates, including antibacterial toxins targeting closely related strains, and the system as a whole has been implicated in a range of activities such as iron acquisition, intercellular signalling, host colonisation and virulence. This review covers the components and secretion mechanism of the T7SSb, the substrates of these systems and their roles in Gram-positive bacteria, with a focus on interbacterial competition.

Publication metadata

Author(s): Boardman ER, Palmer T, Alcock F

Publication type: Review

Publication status: Published

Journal: Microbiology

Year: 2023

Volume: 169

Issue: 12

Online publication date: 20/12/2023

Acceptance date: 06/12/2023

ISSN (print): 1350-0872

ISSN (electronic): 1465-2080

Publisher: Microbiology Society

URL: https://doi.org/10.1099/mic.0.001420

DOI: 10.1099/mic.0.001420

PubMed id: 38116759

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