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Lookup NU author(s): Professor Ann DalyORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2024 The AuthorsIn the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI.
Author(s): Lucena MI, Villanueva-Paz M, Alvarez-Alvarez I, Aithal GP, Bjornsson ES, Cakan-Akdogan G, Cubero FJ, Esteves F, Falcon-Perez JM, Fromenty B, Garcia-Ruiz C, Grove JI, Konu O, Kranendonk M, Kullak-Ublick GA, Miranda JP, Remesal-Doblado A, Sancho-Bru P, Nelson L, Andrade RJ, Daly AK, Fernandez-Checa JC
Publication type: Article
Publication status: Published
Journal: Pharmacological Research
Year: 2024
Volume: 200
Print publication date: 06/01/2024
Online publication date: 28/12/2023
Acceptance date: 20/12/2023
Date deposited: 24/01/2024
ISSN (print): 1043-6618
ISSN (electronic): 1096-1186
Publisher: Academic Press
URL: https://doi.org/10.1016/j.phrs.2023.107046
DOI: 10.1016/j.phrs.2023.107046
PubMed id: 38159783
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