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Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents

Lookup NU author(s): Dr Ankita Das

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Coronary artery disease is the most prevalent cardiovascular disease, claiming millions of lives annually around the world. The current treatment includes surgically inserting a tubular construct, called a stent, inside arteries to restore blood flow. However, due to lack of patient-specific design, the commercial products cannot be used with different vessel anatomies. In this review, we have summarized the drawbacks in existing commercial metal stents which face problems of restenosis and inflammatory responses, owing to the development of neointimal hyperplasia. Further, we have highlighted the fabrication of stents using biodegradable polymers, which can circumvent most of the existing limitations. In this regard, we elaborated on the utilization of new fabrication methodologies based on additive manufacturing such as three-dimensional printing to design patient-specific stents. Finally, we have discussed the functionalization of these stent surfaces with suitable bioactive molecules which can prove to enhance their properties in preventing thrombosis and better healing of injured blood vessel lining.

Publication metadata

Author(s): Das A, Mehrotra S, Kumar A

Publication type: Article

Publication status: Published

Journal: Journal of Functional Biomaterials

Year: 2023

Volume: 14

Issue: 11

Print publication date: 01/11/2023

Online publication date: 10/11/2023

Acceptance date: 07/11/2023

Date deposited: 20/02/2024

ISSN (electronic): 2079-4983

Publisher: MDPI AG

URL: https://doi.org/10.3390/jfb14110544

DOI: 10.3390/jfb14110544

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