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Lookup NU author(s): Anna Stevenson, Leolie Telford-Cooke, Dr Craig Parker, Dr Carmen Martin-RuizORCiD, Professor Raj KalariaORCiD, Dr Elizabeta Mukaetova-Ladinska
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© 2022 - IOS Press. All rights reserved. Background: Myeloperoxidase (MPO), a neutrophil-derived pro-inflammatory protein, co-localizes with amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Anti-dementia treatment may facilitate efflux of Aβ and associated plaque proteins from the brain to the peripheral circulation, therefore providing potential biomarkers for the monitoring of donor response to drug treatment. Objective: We investigated the diagnostic utility of MPO as a biomarker of AD, and how anti-dementia treatment alters plasma MPO concentration. Methods: Thirty-two AD patients were recruited, and plasma collected pre-drug administration (baseline), and 1- and 6-months post-treatment. All patients received cholinesterase inhibitors (ChEIs). At baseline and 6 months, patients underwent neuropsychological assessment. Forty-nine elderly healthy individuals with normal cognitive status served as controls. Plasma MPO concentration was measured by ELISA. Results: AD drug naïve patients had similar plasma MPO concentration to their control counterparts (p > 0.05). Baseline MPO levels positively correlated with Neuropsychiatric Inventory score (r = 0.5080; p = 0.011) and carer distress (r = 0.5022; p = 0.012). Following 1-month ChEI treatment, 84.4% of AD patients exhibited increased plasma MPO levels (p < 0.001), which decreased at 6 months (p < 0.001). MPO concentration at 1 month was greatest in AD patients whose memory deteriorated during the study period (p = 0.028), and for AD patients with deterioration in Cornell assessment score (p = 0.044). Conclusion: Whereas baseline MPO levels did not differentiate between healthy and AD populations, baseline MPO positively correlated with initial Neuropsychiatric Inventory evaluation. Post-treatment, transient MPO upregulation in ChEI-treated patients may reflect worse therapeutic outcome. Further studies are required to assess the potential of plasma MPO as an AD therapeutic biomarker.
Author(s): Wright JR, Deen QFE, Stevenson A, Telford-Cooke LL, Parker C, Martin-Ruiz C, Steinert JR, Kalaria RN, Mukaetova-Ladinska EB
Publication type: Article
Publication status: Published
Journal: Journal of Alzheimer's Disease
Year: 2022
Volume: 89
Issue: 4
Pages: 1483-1492
Print publication date: 11/10/2022
Online publication date: 01/09/2022
Acceptance date: 31/07/2022
ISSN (print): 1387-2877
ISSN (electronic): 1875-8908
Publisher: IOS Press BV
URL: https://doi.org/10.3233/JAD-220642
DOI: 10.3233/JAD-220642
PubMed id: 36057826
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