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Lookup NU author(s): Professor Raj KalariaORCiD, Dr Elizabeta Mukaetova-Ladinska
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Copyright © 2021 Santiago-Mujika, Luthi-Carter, Giorgini, Kalaria and Mukaetova-Ladinska. Alzheimer’s disease (AD) and vascular dementia (VaD) are the two most common forms of dementia in older people. Although these two dementia types differ in their etiology, they share many pathophysiological and morphological features, including neuronal loss, which is associated with the microtubule (MT) destabilization. Stabilization of MTs is achieved in different ways: through interactions with MT binding proteins (MTBP) or by posttranslational modifications (PTMs) of tubulin. Polyglutamylation and tyrosination are two foremost PTMs that regulate the interaction between MTs and MTBPs, and play, therefore, a role in neurodegeneration. In this review, we summarize key information on tubulin PTMs in relation to AD and VaD and address the importance of studying further the tubulin code to reveal sites of potential intervention in development of novel and effective dementia therapy.
Author(s): Santiago-Mujika E, Luthi-Carter R, Giorgini F, Kalaria RN, Mukaetova-Ladinska EB
Publication type: Review
Publication status: Published
Journal: Frontiers in Aging Neuroscience
Year: 2021
Volume: 13
Online publication date: 29/10/2021
Acceptance date: 04/10/2021
ISSN (electronic): 1663-4365
Publisher: Frontiers Media S.A.
URL: https://doi.org/10.3389/fnagi.2021.730107
DOI: 10.3389/fnagi.2021.730107
