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Lookup NU author(s): Dr Gwyndaf RobertsORCiD
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Manufactured nanomaterials (NMs) offer incredible scientific and societal benefits but their potential hazard to human health is not yet fully comprehended. In the last decade, a significant body of evidence indicates that certain NMs are capable of translocating from the primary exposure site (skin, lungs and gastrointestinal tract) to a number of secondary organs which includes the liver. Moreover, recent advances in the field of nanomedicine has resulted in increasing direct intravenous injection of NMs with the liver being a particularly important organ with regards to potential toxic effects and accumulation of said materials. It is generally acknowledged that it is not always possible to make direct or meaningful comparisons between in vitro and in vivo xenobiotic-induced toxicological responses. One of the main reasons for the lack of comparability between the testing strategies is that biological responses are not often alike which can in part be attributed to the numerous limitations of traditional mono-cellular in vitro test systems which are acting as a surrogate for a whole organ. In an attempt to address and highlight this important issue, this chapter will discuss the progress made in the production and validation oof next generation more physiologically relevant multi-cellular in vitro models of skin, GIT and the liver utilised for the assessment of the NM-induced toxicological effects.
Author(s): Kermanizadeh A, Roberts G
Editor(s): Louro H; Silva MJ
Publication type: Book Chapter
Publication status: Published
Book Title: Nanotoxicology in Safety Assessment of Nanomaterials
Year: 2022
Volume: 1357
Pages: 259-273
Print publication date: 19/05/2022
Online publication date: 19/05/2022
Acceptance date: 24/02/2022
Series Title: Advances in Experimental Medicine and Biology (AEMB)
Publisher: Springer
Place Published: Cham
URL: https://doi.org/10.1007/978-3-030-88071-2_11
DOI: 10.1007/978-3-030-88071-2_11
PubMed id: 35583648
Notes: 9783030880712 ebook ISBN.
Library holdings: Search Newcastle University Library for this item
ISBN: 9783030880705
