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N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1

Lookup NU author(s): Professor Derek Mann

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Abstract

Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix metalloproteinase (MMP) inhibition. This has led to further study of novel substrates for MMPs that might impact on HSC survival. N-Cadherin is known to mediate cell-cell contacts in fibroblasts. In this study we demonstrate that N-Cadherin is expressed by activated rat HSC. Furthermore, during apoptosis of HSC, the N-Cadherin is cleaved into smaller fragments. Apoptosis of HSC may be inhibited by TIMP-1. This is associated with reduced fragmentation of N-Cadherin. N-Cadherin may have an important role in supporting HSC survival while N-Cadherin cleavage may play a part in promoting HSC apoptosis in recovery from liver fibrosis.

Publication metadata

Author(s): Murphy F, Waung J, Collins J, Arthur MJ, Nagase H, Mann D, Benyon RC, Iredale JP

Publication type: Article

Publication status: Published

Journal: Comparative Hepatology

Year: 2004

Volume: 3

Issue: s1

Date deposited: 14/11/2011

ISSN (print): 1476-5926

ISSN (electronic): 1476-5926

Publisher: BioMed Central Ltd.

URL: http://dx.doi.org/10.1186/1476-5926-2-S1-S8

DOI: 10.1186/1476-5926-2-S1-S8

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