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The Role of Inhibitors of Poly(Adp-Ribose) Polymerase as Resistance-Modifying Agents in Cancer-Therapy

Lookup NU author(s): Professor Roger Griffin, Professor Nicola Curtin, Professor Herbie Newell, Professor Bernard Golding, Emeritus Professor Barbara Durkacz, Professor Alan Calvert

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Abstract

Poly(ADP-ribose) polymerase (PARP) plays an important role in a number of cellular processes including DNA repair. Since poly(ADP-ribosyl)ation occurs in response to radiation- or drag-induced DNA damage, inhibitors of the enzyme may enhance the antitumour activity of radiotherapy or cytotoxic drug treatment. In this review the development of PARP inhibitors is discussed, and structure-activity relationships amongst inhibitors of the enzyme are presented. Studies to date regarding the in vitro and in vivo activity of PARP inhibitors, as resistance modifying agents in cancer therapy, are also overviewed.


Publication metadata

Author(s): Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH

Publication type: Article

Publication status: Published

Journal: Biochimie

Year: 1995

Volume: 77

Issue: 6

Pages: 408-422

Print publication date: 01/02/1995

ISSN (print): 0300-9084

ISSN (electronic): 1638-6183

URL: http://dx.doi.org/10.1016/0300-9084(96)88154-5

DOI: 10.1016/0300-9084(96)88154-5


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