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Crystals in hand

Lookup NU author(s): Professor John Loughlin

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Abstract

A genetic association of the ENPP1 gene with primary hand osteoarthritis was recently reported in this journal. ENPP1 encodes an enzyme that regulates soft tissue calcification. The study as it stands is far from complete because the actual causal variant(s) within ENPP1 has not been identified and no functional study on the activity of the enzyme in hand osteoarthritis was presented. Nevertheless, the study stimulates interest and will encourage others in the field to test ENPP1 as a possible osteoarthritis susceptibility gene in their cohorts. The genetic basis of osteoarthritis is slowly being uncovered, and this report constitutes another interesting find.


Publication metadata

Author(s): Loughlin J

Publication type: Article

Publication status: Published

Journal: Arthritis Research & Therapy

Year: 2005

Volume: 7

Issue: 5

Pages: 187-188

ISSN (print): 1478-6354

ISSN (electronic): 1478-6362

Publisher: BioMed Central Ltd.

URL: http://dx.doi.org/10.1186/ar1807

DOI: 10.1186/ar1807


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