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Tregs and rheumatoid arthritis

Lookup NU author(s): Dr Amy Anderson, Professor John Isaacs

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Abstract

Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.


Publication metadata

Author(s): Anderson AE, Isaacs JD

Publication type: Article

Publication status: Published

Journal: Acta Reumatológica Portuguesa

Year: 2008

Volume: 33

Issue: 1

Pages: 17-33

Print publication date: 01/03/2008

ISSN (print): 0303-464X

Publisher: Sociedade Portuguesa de Reumatologia

URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18344919

Notes: Journal Article Portugal


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