Lookup NU author(s): Dr Michael Hall
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The preparation of the C1–C11 subunit of phoslactomycins, and a formal synthesis of phoslactomycin B, were achieved by a convergent strategy involving the chelation-controlled addition of an alkynyl Grignard reagent to a α-alkoxyketone. Catalytic enantioselective reductions of acetylenic ketones and a [2,3]-Wittig rearrangement were utilized as key steps to control the configuration of the C4, C5 and C9 stereocenters.
Author(s): Druais V, Hall MJ, Corsi C, Wendeborn SV, Meyer C, Cossy J
Publication type: Article
Publication status: Published
Journal: Organic Letters
Print publication date: 19/02/2009
ISSN (print): 1523-7060
ISSN (electronic): 1523-7052
Publisher: American Chemical Society
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