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Lookup NU author(s): Dr Ian CowellORCiD, Heather Morrison
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We show that methylated lysine 9 of histone H3 (Me9H3) is a marker of heterochromatin in divergent animal species. It localises to both constitutive and facultative heterochromatin and replicates late in S-phase of the cell cycle. Significantly, Me9H3 is enriched in the inactive mammalian X chromosome (Xi) in female cells, as well as in the XY body during meiosis in the male, and forms a G-band pattern along the arms of the autosomes. Me9H3 is a constituent of imprinted chromosomes that are repressed. The paternal and maternal pronuclei in one-cell mouse embryos show a striking non-equivalence in Me9H3: the paternal pronucleus contains no immunocytologically detectable Me9H3. The levels of Me9H3 on the parental chromosomes only become equivalent after the two-cell stage. Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA
Author(s): Cowell IG, Aucott R, Mahadevaiah SK, Burgoyne PS, Huskisson NS, Bongiorni S, Prantera G, Fanti L, Pimpinelli S, Wu R, Gilbert D, Shi W, Fundele R, Morrison H, Jeppesen P, Singh PB
Publication type: Article
Publication status: Published
Journal: Chromosoma
Year: 2002
Volume: 111
Issue: 1
Pages: 22-36
ISSN (print): 0009-5915
ISSN (electronic): 1432-0886
Publisher: Springer Berlin
URL: http://dx.doi.org/10.1007/s00412-002-0182-8
DOI: 10.1007/s00412-002-0182-8
PubMed id: 12068920
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