Lookup NU author(s): Dr Chris Redfern,
Professor Ann Daly,
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The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
Author(s): Redfern CPF, Daly AK, Latham JAE, Todd C
Publication type: Article
Publication status: Published
Journal: FEBS Letters
Print publication date: 29/10/1990
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
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