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The biological activity of retinoids in melanoma cells: Induction of expression of retinoic acid receptor-β by retinoic acid in S91 melanoma cells

Lookup NU author(s): Dr Chris Redfern, Professor Ann Daly, Carole Todd

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Abstract

The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.


Publication metadata

Author(s): Redfern CPF, Daly AK, Latham JAE, Todd C

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 1990

Volume: 273

Issue: 1-2

Pages: 19-22

Print publication date: 29/10/1990

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

URL: http://dx.doi.org/10.1016/0014-5793(90)81041-L

DOI: 10.1016/0014-5793(90)81041-L

Notes: 0014-5793 Journal Article


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