Toggle Main Menu Toggle Search

Open Access padlockePrints

Mismatch repair defects as a cause of resistance to cytotoxic drugs

Lookup NU author(s): Professor Julie Irving, Dr Andrew Hall

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.


Publication metadata

Author(s): Irving JAE, Hall AG

Publication type: Review

Publication status: Published

Journal: Expert Review of Anticancer Therapy

Year: 2001

Volume: 1

Issue: 1

Pages: 149-158

Print publication date: 01/01/2001

ISSN (print): 1473-7140

ISSN (electronic): 1744-8328

URL: http://dx.doi.org/10.1586/14737140.1.1.149

DOI: 10.1586/14737140.1.1.149

PubMed id: 12113123


Share