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Linkage analysis of chromosome 2q in osteoarthritis

Lookup NU author(s): Professor John Loughlin, Dr Kaye Chapman

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Abstract

BACKGROUND: In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA). OBJECTIVE: To test chromosome 2q for linkage to idiopathic osteoarthritis. METHODS: Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM. RESULTS: Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132). CONCLUSIONS: Chromosome 2q is likely to contain at least one susceptibility locus for OA.


Publication metadata

Author(s): Loughlin J; Chapman KE; Mustafa Z; Smith A; Irven C; Carr AJ; Clipsham K; Chitnavis J; Bloomfield VA; McCartney M; Cox O; Sinsheimer JS; Sykes B

Publication type: Article

Publication status: Published

Journal: Rheumatology

Year: 2000

Volume: 39

Issue: 4

Pages: 377-381

ISSN (print): 1462-0324

ISSN (electronic): 1662-3959

Publisher: S Karger AG

URL: http://dx.doi.org/10.1093/rheumatology/39.4.377

DOI: 10.1093/rheumatology/39.4.377

Notes: Journal Article Research Support, Non-U.S. Gov't England


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