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The pathogenesis of drug-induced gingival overgrowth

Lookup NU author(s): Emeritus Professor Robin Seymour

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Abstract

Gingival overgrowth is a well-documented unwanted effect, associated with phenytoin, cyclosporin, and the calcium channel blockers. The pathogenesis of drug-induced gingival overgrowth is uncertain, and there appears to be no unifying hypothesis that links together the 3 commonly implicated drugs. In this review, we consider a multifactorial model which expands on the interaction between drug and/or metabolite, with the gingival fibroblasts. Factors which impact upon this model include age, genetic predisposition, pharmacokinetic variables, plaque-induced inflammatory and immunological changes and acti vation of growth factors. Of these, genetic factors which give rise to fibroblast heterogeneity, gingival inflammation, and pharmacokinetic variables appear to be significant in the expression of gingival overgrowth. A more thorough understanding of the pathogenesis of this unwanted effect will hopefully elucidate appropriate mechanisms for its control. © Munksgaard, 1996.

Publication metadata

Author(s): Seymour RA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 1996

Volume: 23

Issue: 3

Pages: 165-175

Print publication date: 01/01/1996

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: Wiley-Blackwell Publishing

URL: http://dx.doi.org/10.1111/j.1600-051X.1996.tb02072.x

DOI: 10.1111/j.1600-051X.1996.tb02072.x

PubMed id: 8707974

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