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Striatal dopaminergic loss without parkinsonism in a case of corticobasal degeneration

Lookup NU author(s): Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry, Dr Margaret Piggott, Dr Evelyn Jaros, Professor David Burn

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Abstract

Neurochemical analyses of post-mortem brain from cases of corticobasal degeneration are extremely rare although nearly 100 cases have been reported in the literature. We detail findings of neurotransmitter derangement in the basal ganglia of a case of neuropathologically confirmed corticobasal degeneration, who presented with dementia. The implications of severe neuronal loss in the substantia nigra and extremely low levels of dopamine and its metabolites in the striatum are considered in relation to the absence of an intrinsic extrapyramidal syndrome.

Publication metadata

Author(s): Marshall EF, Perry RH, Perry EK, Piggott MA, Thompson P, Jaros E, Burn DJ

Publication type: Article

Publication status: Published

Journal: Acta Neurologica Scandinavica

Year: 1997

Volume: 95

Issue: 5

Pages: 287-292

Print publication date: 01/01/1997

ISSN (print): 0001-6314

ISSN (electronic): 1600-0404

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1111/j.1600-0404.1997.tb00212.x

DOI: 10.1111/j.1600-0404.1997.tb00212.x

PubMed id: 9188904

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