Lookup NU author(s): Emmett O'Flaherty,
Professor John Kirby
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Metastasis and the processes underlying this phenomenon make epithelial cancers so malignant. Local control of cancers by surgery is sometimes possible but locoregional and distant recurrence commonly lead to the failure of treatment with ensuing morbidity and mortality. Tumour cells express a range of new antigens during growth and there are opportunities for the host immune system to interact with these antigens. This immune interaction eliminates the tumour or allows selection of phenotypic variants. Cell phenotypes selected by an incomplete immune response resemble the cell type commonly associated with metastases. Thus we propose that the host immune system may be responsible for selection of this phenotype and progression of the disease.
Author(s): Kirby JA; O'Flaherty E; Charnley RM; Seymour K; Pettit S
Publication type: Article
Publication status: Published
Print publication date: 04/12/1999
ISSN (print): 0140-6736
ISSN (electronic): 1474-547X
Publisher: The Lancet Publishing Group
PubMed id: 10622313
Altmetrics provided by Altmetric