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CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease

Lookup NU author(s): Emeritus Professor Robert Perry, Professor Ian McKeith, Dr Andrew Fairbairn, Professor Jim Edwardson, Professor Ann Daly, Dr Christopher Morris

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Abstract

The similarities between the clinical and pathological findings of dementia with Lewy Bodies (DLB) with Alzheimer's disease and Parkinson's disease are complex, and their significance for pathogenesis is unresolved. It is likely that DLB shares common disease determinants with both Alzheimer's disease and Parkinson's disease. Clinically DLB shows the presence of dementia similar, though not identical, to that found in Alzheimer's disease. A parkinsonian movement disorder is present in a proportion of DLB cases. Pathologically DLB shows senile plaques, as with Alzheimer's disease, and also substantia nigra neurone loss and Lewy bodies, as with Parkinson's disease. At a genetic level, DLB shows an elevated Apolipoprotein E ε4 frequency as described in Alzheimer's disease, but this is absent in Parkinson's disease. An elevated frequency of the CYP2D6*4 allele has been found in Parkinson's disease and we have therefore genotyped a large series of clinically and neuropathologically confirmed cases of DLB, Alzheimer's disease, Parkinson's disease and age-matched control individuals for the CYP2D6*4 allele. Whilst an elevated frequency of the CYP2D6*4 allele was found in Parkinson's disease, no such elevations were found in DLB or Alzheimer's disease. Stratification of the CYP2D6*4 allele with respect to the Apolipoprotein E ε4 also did not show any significant associations with the CYP2D6*4 allele. The CYP2D6*4 allele is not a major genetic determinant of DLB and the results place DLB with Alzheimer's disease rather than Parkinson's disease on a genetic level.


Publication metadata

Author(s): Daly AK; McKeith IG; Fairbairn AF; Edwardson JA; Perry RH; Morris CM; Atkinson A; Singleton AB; Steward A; Ince PG

Publication type: Article

Publication status: Published

Journal: Pharmacogenetics and Genomics

Year: 1999

Volume: 9

Issue: 1

Pages: 31-36

Print publication date: 01/02/1999

ISSN (print): 0960314X

ISSN (electronic):

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/00008571-199902000-00005

DOI: 10.1097/00008571-199902000-00005

PubMed id: 10208640


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