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The connectional organization of the cortico-thalamic system of the cat

Lookup NU author(s): Dr Jack Scannell, Professor Malcolm Young

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Abstract

Data on connections between the areas of the cerebral cortex and nuclei of the thalamus are too complicated to analyse with naked intuition. Indeed, the complexity of connection data is one of the major challenges facing neuroanatomy. Recently, systematic methods have been developed and applied to the analysis of the connectivity in the cerebral cortex. These approaches have shed light on the gross organization of the cortical network, have made it possible to test systematically theories of cortical organization, and have guided new electrophysiological studies. This paper extends the approach to investigate the organization of the entire corticothalamic network. An extensive collation of connection tracing studies revealed ~1500 extrinsic connections between the cortical areas and thalamic nuclei of the cat cerebral hemisphere. Around 850 connections linked 53 cortical areas with each other, and around 650 connections linked the cortical areas with 42 thalamic nuclei. Non-metric multidimensional scaling, optimal set analysis and non-parametric cluster analysis were used to study global connectivity and the 'place' of individual structures within the overall scheme. Thalamic nuclei and cortical areas were in intimate connectional association. Connectivity defined four major thalamocortical systems. These included three broadly hierarchical sensory or sensory/motor systems (visual and auditory systems and a single system containing both somatosensory and motor structures). The highest stations of these sensory/motor systems were associated with a fourth processing system composed of prefrontal, cingulate, insular and parahippocampal cortex and associated thalamic nuclei (the 'fronto-limbic system'). The association between fronto-limbic and somato- motor systems was particularly close.


Publication metadata

Author(s): Scannell JW, Burns GAPC, Hilgetag CC, O'Neil MA, Young MP

Publication type: Article

Publication status: Published

Journal: Cerebral Cortex

Year: 1999

Volume: 9

Issue: 3

Pages: 277-299

Print publication date: 01/01/1999

ISSN (print): 1047-3211

ISSN (electronic): 1460-2199

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/cercor/9.3.277

DOI: 10.1093/cercor/9.3.277

PubMed id: 10355908


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