Lookup NU author(s): Dr Quentin Campbell Hewson,
Professor Penny Lovat,
Professor Archibald Malcolm,
Professor Andrew Pearson,
Dr Chris Redfern
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The aim of this study was to clarify retinoid receptor mechanisms mediating the effects of 9-cis retinoic acid (RA) and investigate the ability of RAR- and RXR-specific analogues to induce differentiation and inhibit proliferation in neuroblastoma cells. Differentiation and the inhibition of proliferation by 9-cis RA, but not all-trans RA, were inhibited by the RXR-homodimer antagonist LG745. The RXR-specific agonist LGD1069 was ineffective at inducing differentiation or inhibiting proliferation, but showed marked synergism with RAR-specific agonists with respect to inhibiting proliferation. These data suggest that the effects of 9-cis RA are mediated via both RXR-homodimers and heterodimers. However, combinations of RAR- and RXR-selective analogues were not as effective at promoting differentiation. This study indicates that different receptor mechanisms are involved in retinoid-induced differentiation and inhibition of proliferation in neuroblastoma cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Author(s): Campbell-Hewson, Q., Lovat, P.E., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F.
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Print publication date: 28/01/2000
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
PubMed id: 10674634
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