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Individual variation in somatic mutations of the glycophorin-A gene in neonates in relation to pre-natal factors

Lookup NU author(s): Professor Louise Parker, Professor Sir John Burn

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Abstract

The frequency of somatic mutations of the glycophorin-A (GPA) gene was measured in red blood cells from a series of newborn babies and related to various epidemiological and lifestyle factors in order to identify those factors that might influence the mutation rate before birth. Although there was substantial variation in the mutation frequencies between individual babies, no specific associations were found with any of the factors explored including smoking, age and social class of the parents, and gender and birth weight of the babies. It is concluded that these factors do not have a substantial effect on the mutational endpoint measured, although this does not necessarily mean that they have no effect on health risk to the offspring. The observed variation in GPA gene mutation frequency must, therefore, be due either to exposure to less obvious external influences or to intrinsic factors. Copyright (C) 2000 Elsevier Science B.V.


Publication metadata

Author(s): Daniel CP, Fisher A, Parker L, Burn J, Tawn EJ

Publication type: Article

Publication status: Published

Journal: Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Year: 2000

Volume: 467

Issue: 2

Pages: 153-159

ISSN (print): 1383-5718

ISSN (electronic):

Publisher: Elsevier B.V.

URL: http://dx.doi.org/10.1016/S1383-5718(00)00031-0

DOI: 10.1016/S1383-5718(00)00031-0

PubMed id: 10838202


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