Lookup NU author(s): Simon Selwood,
Professor Zofia Chrzanowska-Lightowlers,
Professor Robert Lightowlers
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The mechanism of mitochondrial transcription is well documented although the method of regulation remains obscure. The mitochondrial transcription-termination complex, mTERF, holds a key position in determining the fate of heavy-strand promotor-initiated transcripts and has been suggested as a candidate in the regulation of mitochondrial DNA (mtDNA) transcription. We report here the first example of a modulation of mTERF-complex binding activity concomitant with a differential mtDNA transcription rate. We suggest that these observations are indicative of a method of intra-organellar transcriptional fine tuning.
Author(s): Selwood SP, Chrzanowska-Lightowlers ZMA, Lightowlers RN
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Colloquium on Organisms, Organs, Cells and Organelles - In Vivo and In Vitro Experimental Systems
Year of Conference: 2000
Publisher: Biochemical Society Transactions, Portland Press
PubMed id: 10816118
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