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Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats

Lookup NU author(s): Dr Johnny RoughanORCiD, Emeritus Professor Paul FlecknellORCiD

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Abstract

Two groups of rats were anaesthetized at weekly intervals for 6 weeks with either ketamine/medetomidine alone (60 mg/0.4 mg/kg i.p.) or ketamine/medetomidine (45 mg/0.3 mg/kg i.p.) one hour following buprenorphine (0.05 mg/kg s.c.). Animals that received buprenorphine had longer periods of surgical anaesthesia (P = 0.04) and a greater depression of both mean pedal withdrawal score (P < 0.01) and mean respiratory rate (P = 0.014). Mean total duration of anaesthesia was also greater in the buprenorphine group on day 1. Sleep times reduced with successive doses of anaesthetic in the buprenorphine group (P = 0.024). Two animals in the buprenorphine group died. Repeated anaesthesia with ketamine/medetomidine alone was not associated with anaesthetic mortality. These results indicate that although buprenorphine has a clear anaesthetic-sparing effect, its use with ketamine/medetomidine may be associated with an increased risk of anaesthetic-related mortality.

Publication metadata

Author(s): Roughan JV; Flecknell PA; Hedenqvist P

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2000

Volume: 34

Issue: 2

Pages: 207-211

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd

URL: http://dx.doi.org/10.1258/002367700780457536

DOI: 10.1258/002367700780457536

PubMed id: 10817461

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