Lookup NU author(s): Professor Jeremy Lakey
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The pore-forming colicins, the first proteins that were capable of forming voltage-dependent ion channels to be sequenced, have turned out to be both less tractable and more mysterious than imagined; yet they have proved interesting at every step of their short journey from producing cell to vanquished target cell. Starting out as a remarkably extended water-soluble protein, the colicin molecule is designed to interact simultaneously with several components of the complex membrane of the target cell, transform itself into a membrane protein, and become an ion channel with inscrutable properties. Unraveling how it does all this appears to be leading us into the dark recesses of protein/protein and protein/membrane interaction, where lurk fundamental processes reluctantly waiting to be revealed.
Author(s): Lakey JH, Slatin SL
Publication type: Review
Publication status: Published
Journal: Current Topics in Microbiology and Immunology
Print publication date: 01/01/2001
ISSN (print): 0070-217X
PubMed id: 11417119