Lookup NU author(s): Professor Derek Manas,
Professor Simi Ali,
Professor John Kirby,
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
To analyse the contribution of cytomegalovirus (CMV) serology to long-term graft survival in cadaveric kidney transplantation, 404 transplants from a single centre were divided into four subgroups with respect to the combination of donor and recipient CMV antibody status. Graft survival was estimated according to Kaplan-Meier for 1, 3, 5 and 7 years post-transplantation. The single-centre results confirm a negative impact of CMV-positive donor organs for initial graft survival in CMV-negative recipients within the first 3 years after transplantation. However, when 5- and 7-year long-term graft survival was studied, Donor +/Recipient - pairs showed a favourable long-term result, whilst D +/R - pairs had surprisingly a poorer outcome. Therefore, the concept of avoiding transplantation in the D +/R + CMV serology group should be ignored whereas attempts could be made to improve the poor long-term outcome of D +/R + pairs or to reduce its size by organ allocation. © Springer-Verlag 2000.
Author(s): Gerstenkorn C, Balupuri S, Mohamed MA, Manas DM, Ali S, Kirby J, Talbot D
Publication type: Article
Publication status: Published
Journal: Transplant International
Print publication date: 01/01/2000
ISSN (print): 0934-0874
ISSN (electronic): 1432-2277
Publisher: Wiley-Blackwell Publishing Ltd.
PubMed id: 11112035
Altmetrics provided by Altmetric