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The impact of cytomegalovirus serology for 7-year graft survival in cadaveric kidney transplantation - The Newcastle experience

Lookup NU author(s): Professor Derek Manas, Professor Simi Ali, Emeritus Professor John Kirby, David Talbot

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Abstract

To analyse the contribution of cytomegalovirus (CMV) serology to long-term graft survival in cadaveric kidney transplantation, 404 transplants from a single centre were divided into four subgroups with respect to the combination of donor and recipient CMV antibody status. Graft survival was estimated according to Kaplan-Meier for 1, 3, 5 and 7 years post-transplantation. The single-centre results confirm a negative impact of CMV-positive donor organs for initial graft survival in CMV-negative recipients within the first 3 years after transplantation. However, when 5- and 7-year long-term graft survival was studied, Donor +/Recipient - pairs showed a favourable long-term result, whilst D +/R - pairs had surprisingly a poorer outcome. Therefore, the concept of avoiding transplantation in the D +/R + CMV serology group should be ignored whereas attempts could be made to improve the poor long-term outcome of D +/R + pairs or to reduce its size by organ allocation. © Springer-Verlag 2000.

Publication metadata

Author(s): Gerstenkorn C, Balupuri S, Mohamed MA, Manas DM, Ali S, Kirby J, Talbot D

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2000

Volume: 13

Issue: 1

Pages: S372-S374

Print publication date: 01/01/2000

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1007/s001470050364

DOI: 10.1007/s001470050364

PubMed id: 11112035

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