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Differences between human and mouse alpha-fetoprotein expression during early development

Lookup NU author(s): Dr Elizabeth Jones, Dr Mark Clement-Jones, Emeritus Professor Oliver James, Dr David Wilson

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Abstract

Alpha-fetoprotein (AFP) is the major serum protein during development. AFP is one of the earliest proteins to be synthesised by the embryonic liver. The synthesis of AFP decreases dramatically after birth and only trace amounts are expressed in the adult liver. The tissue distribution of AFP in early human embryogenesis has not been defined. We have studied the expression pattern of AFP mRNA in human and mouse embryos by in situ hybridisation. In humans, AFP is expressed in the hepatic diverticulum at 26 d postovulation as it differentiates from the foregut endoderm (i.e. in the most primitive hepatocytes). It is also expressed in the endoderm of the gastrointestinal tract and in the yolk sac at this age. AFP is subsequently expressed in the mesonephros and transiently in the developing pancreas. In the mouse, no expression of AFP was observed in the mesonephros but other sites of expression were similar. Thus AFP has a distinct temporospatial expression pattern during the embryonic period and this differs between human and mouse species. It is interesting that AFP is expressed by tumours such as primitive gastrointestinal, renal cell and pancreatic tumours as well as those of hepatocyte origin. This distribution reflects the sites of AFP expression during development.


Publication metadata

Author(s): Jones EA; James OFW; Clement-Jones M; Wilson DI

Publication type: Article

Publication status: Published

Journal: Journal of Anatomy

Year: 2001

Volume: 198

Issue: 5

Pages: 555-559

Print publication date: 01/01/2001

ISSN (print): 0021-8782

ISSN (electronic): 1469-7580

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1017/S0021878201007634

DOI: 10.1017/S0021878201007634

PubMed id: 11430694


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