Lookup NU author(s): Clayton Price,
Dr Mark Elsegood,
Emeritus Professor Bill Clegg,
Professor Andrew Houlton
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The reactions of PdII ions with a series of chelate-tethered derivatives of adenine and guanine have been studied and reveal a difference in the reactivity of the purine bases. Reactions of [PdCl2(MeCN)2] and A-alkyl-enH · Cl (alkyl = propyl or ethyl, A = adenine, en = ethylenediamine) yield the monocationic species [PdCl(A-N3-Et-en)]+ (1) and [PdCl(A-N3-Pr-en)]+ (2). Both involve co-ordination at the minor groove site N3 of the nucleobase as confirmed by single-crystal X-ray analysis. Reactions with the analogous G-alkyl-enH · Cl derivatives (G = guanine, alkyl = ethyl or propyl) were more complex with a mixture of species being observed. For G-Et-en · HCl a product was isolated which was identified as [PdCl(G-C8-Et-en)]+ (3). This compound contains a biomolecular metal-carbon bond involving C8 of the purine base. Crystallography of a product obtained from reaction of G-Pr-enH · Cl and [Pd(MeCN)4][NO3]2 reveals an octacationic tetrameric complex (4), in which each ligand acts to bridge two metal ions through a combination of a tridentate binding mode involving the diamine and N3 and monodentate coordination at N7.
Author(s): Elsegood MRJ; Shipman MA; Clegg W; Houlton A; Price C; Rees NH; Edwards AJ
Publication type: Article
Publication status: Published
Journal: Chemistry - A European Journal
ISSN (print): 0947-6539
ISSN (electronic): 1521-3765
Publisher: Wiley - VCH Verlag GmbH & Co
PubMed id: 11322545
Altmetrics provided by Altmetric