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Lookup NU author(s): Professor Anne Dickinson, Dr Jennifer Cavet, Dr Hannah Cullup, Dr Xiao WangORCiD, Dr Peter Middleton
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This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor α, interferon γ, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in predicting outcome and the development of a genetic risk index for graft-versus-host disease in human leukocyte antigen matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain polymorphisms may be associated with more severe disease. © American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
Author(s): Dickinson AM, Cavet J, Cullup H, Wang XN, Sviland L, Middleton PG
Publication type: Article
Publication status: Published
Journal: Human Immunology
Year: 2001
Volume: 62
Issue: 11
Pages: 1266-1276
Print publication date: 01/01/2001
ISSN (print): 0198-8859
ISSN (electronic): 1879-1166
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/S0198-8859(01)00324-X
DOI: 10.1016/S0198-8859(01)00324-X
PubMed id: 11704290
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