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Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

Lookup NU author(s): Professor Alexander Burkle

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Abstract

Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is an immediate cellular reaction to DNA strand breakage as induced by alkylating agents, ionizing radiation or oxidants. The resulting formation of protein-coupled poly(ADP-ribose) facilitates survival of proliferating cells under conditions of DNA damage, probably via its contribution to DNA base-excision repair. Furthermore, based on recent results there is a role emerging for PARP-1 as a negative regulator of genomic instability in cells under genotoxic stress. Regarding possible applications for clinical cancer therapy with DNA-damaging agents, it appears that both inhibition and up-regulation of the poly(ADP-ribosyl)ation response in the malignant cells to be eradicated are promising strategies to improve the outcome of such therapy, albeit for different reasons. © 2001 Elsevier Science Ireland Ltd.

Publication metadata

Author(s): Burkle A

Publication type: Note

Publication status: Published

Journal: Cancer Letters

Year: 2001

Volume: 163

Issue: 1

Pages: 1-5

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

URL: http://dx.doi.org/10.1016/S0304-3835(00)00694-7

DOI: 10.1016/S0304-3835(00)00694-7

PubMed id: 11163101

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