Lookup NU author(s): Emeritus Professor Robert Perry,
Professor Andrew Pearson,
Professor John Lunec
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One hundred and one pre-treatment primary central pnmitive neuroectodermal tumours were analysed for the expression of p53 protein by immunohistochemistry using the monoclonal antibody DO-7. The staining intensity was classified into four groups: strong, medium, weak and negative and strong staining intensity was associated with the poorest survival. DNA sequencing of the p53 gene was performed in 28 cases representing all four staining groups. Mutations were found in only three of the strong staining tumours suggesting that DNA mutations were not common events and that in the majority of the tumours with over-expressed p53, the protein was likely to be wild-type. Results of immunohistochemistry showed a significantly positive relationship between the expression of p53 and Bax and Bcl-2 proteins, but not Waf-1. Multivariate analyses supported the prognostic value of p53 immunostaining in central primitive neuroectodermal tumours and also of age and gender of patients. © 2002 Cancer Research UK.
Author(s): Burns, A.S.Y.W., Jaros, E., Cole, M., Perry, R., Pearson, A.D.J., Lunec, J.
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Print publication date: 08/04/2002
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
PubMed id: 11953859
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