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The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system

Lookup NU author(s): Alice Burns, Dr Evelyn Jaros, Mike Cole, Emeritus Professor Robert Perry, Professor Andrew Pearson, Professor John Lunec

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Abstract

One hundred and one pre-treatment primary central pnmitive neuroectodermal tumours were analysed for the expression of p53 protein by immunohistochemistry using the monoclonal antibody DO-7. The staining intensity was classified into four groups: strong, medium, weak and negative and strong staining intensity was associated with the poorest survival. DNA sequencing of the p53 gene was performed in 28 cases representing all four staining groups. Mutations were found in only three of the strong staining tumours suggesting that DNA mutations were not common events and that in the majority of the tumours with over-expressed p53, the protein was likely to be wild-type. Results of immunohistochemistry showed a significantly positive relationship between the expression of p53 and Bax and Bcl-2 proteins, but not Waf-1. Multivariate analyses supported the prognostic value of p53 immunostaining in central primitive neuroectodermal tumours and also of age and gender of patients. © 2002 Cancer Research UK.


Publication metadata

Author(s): Burns, A.S.Y.W., Jaros, E., Cole, M., Perry, R., Pearson, A.D.J., Lunec, J.

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 2002

Volume: 86

Issue: 7

Pages: 1117-1123

Print publication date: 08/04/2002

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

URL: http://dx.doi.org/10.1038/sj.bjc.6600151

DOI: 10.1038/sj.bjc.6600151

PubMed id: 11953859


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