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Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin

Lookup NU author(s): Dr Emma Meczes, Professor Andrew Pearson, Professor Caroline Austin, Dr Michael Tilby

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Abstract

The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. © 2002 The Cancer Research Campaign.


Publication metadata

Author(s): Meczes, E., Pearson, A.D.J., Austin, C.A., Tilby, M.J.

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 2002

Volume: 86

Issue: 3

Pages: 485-489

Print publication date: 01/02/2002

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

URL: http://dx.doi.org/10.1038/sj.bjc.6600060

DOI: 10.1038/sj.bjc.6600060

PubMed id: 11875719


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