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Peeking into a secret world of pore-forming toxins: Membrane binding processes studied by surface plasmon resonance

Lookup NU author(s): Professor Jeremy Lakey

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Abstract

Pore-formation in cell membranes is used by many toxins to kill cells. It is usually a process involving multiple steps that are difficult to analyse at the molecular level. The use of surface plasmon resonance (SPR) has only recently been introduced into the study of pore-forming toxins (PFT). It can give useful data mostly on the first steps of the pore-forming process; the binding to the lipid membranes. In particular, it can make unique contributions to our knowledge of ligand specificity and the kinetics of binding. This mini-review summarizes some recent SPR studies of PFT. © 2003 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Anderluh G, Macek P, Lakey JH

Publication type: Note

Publication status: Published

Journal: Toxicon

Year: 2003

Volume: 42

Issue: 3

Pages: 225-228

Print publication date: 01/09/2003

ISSN (print): 0041-0101

ISSN (electronic): 1879-3150

URL: http://dx.doi.org/10.1016/S0041-0101(03)00197-1

DOI: 10.1016/S0041-0101(03)00197-1

PubMed id: 14559072


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