Lookup NU author(s): Professor Jeremy Lakey
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Pore-formation in cell membranes is used by many toxins to kill cells. It is usually a process involving multiple steps that are difficult to analyse at the molecular level. The use of surface plasmon resonance (SPR) has only recently been introduced into the study of pore-forming toxins (PFT). It can give useful data mostly on the first steps of the pore-forming process; the binding to the lipid membranes. In particular, it can make unique contributions to our knowledge of ligand specificity and the kinetics of binding. This mini-review summarizes some recent SPR studies of PFT. © 2003 Elsevier Ltd. All rights reserved.
Author(s): Anderluh G, Macek P, Lakey JH
Publication type: Note
Publication status: Published
Print publication date: 01/09/2003
ISSN (print): 0041-0101
ISSN (electronic): 1879-3150
PubMed id: 14559072