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Warfarin sensitivity: Be aware of genetic influence

Lookup NU author(s): Professor Farhad Kamali, Professor Ann Daly, Dr Hilary Wynne

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Abstract

Background: Avoidance of over anticoagulation in response to warfarin therapy would reduce risk of associated bleeding. Subjects: 5wo elderly patients with venous thromboembolism exhibited extreme anticoagulant response to warfarin. Both were noted to have variant CYP2C9 alleles, which reduce the metabolic capacity of cytochrome P450 2C9. Discussion: Adverse outcomes with warfarin therapy could be explained and possibly avoided by identifying patients with variant alleles for CYP2C9 before initiation of therapy.


Publication metadata

Author(s): Khan T, Kamali F, Daly A, King B, Wynne HA

Publication type: Article

Publication status: Published

Journal: Age and Ageing

Year: 2003

Volume: 32

Issue: 2

Pages: 226-227

Print publication date: 01/03/2003

ISSN (print): 0002-0729

ISSN (electronic): 1468-2834

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ageing/32.2.226

DOI: 10.1093/ageing/32.2.226

PubMed id: 12615570


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