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Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia

Lookup NU author(s): Dr Carmen Martin-Ruiz, Professor Allan Young, Emeritus Professor Elaine Perry, Dr Jennifer Court

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Abstract

Background: The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia. Methods: The present study investigates possible associations of nicotinic receptor subunit expression in the dorsal lateral prefrontal cortex, an area known to be affected in schizophrenia, and dementia rating. Results: α7 immunoreactivity was reduced by 20% to 28% and [3H]epibatidine binding was increased twofold in groups of patients with schizophrenia compared to normal control subjects matched for age, postmortem delay, and low levels of brain nicotine and cotinine. In contrast, no significant differences in α4, α3, or β2 immunoreactivity or α7 messenger RNA expression were observed in schizophrenia patients compared with control subject values. Clinical dementia ratings in patients with schizophrenia were correlated with neither [3H]epibatidine binding nor nicotinic receptor subunit expression. Conclusions: These data indicate no relationship between the trend for reduced neocortical α7 subunit protein expression in schizophrenia and dementia. Further investigations are required to establish whether the reduction in α7 protein in the dorsal lateral prefrontal cortex is associated with clinical features other than dementia in schizophrenia. © 2003 Society of Biological Psychiatry.


Publication metadata

Author(s): Martin-Ruiz CM, Haroutunian VH, Long P, Young AH, Davis KL, Perry EK, Court JA

Publication type: Article

Publication status: Published

Journal: Biological Psychiatry

Year: 2003

Volume: 54

Issue: 11

Pages: 1222-1233

ISSN (print): 0006-3223

ISSN (electronic): 1873-2402

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0006-3223(03)00348-2

DOI: 10.1016/S0006-3223(03)00348-2

PubMed id: 14643090


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