Lookup NU author(s): Professor Bernard Golding
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The synthesis of the useful reagent for the preparation of guanidines, 3,5-dimethyl-N-nitro-1-pyrazole-1-carboxamidine (DMNPC), has been optimised. A detailed protocol for using this reagent for the preparation in pure form of a range of guanidines via nitroguanidines is described. A comparison has been made regarding efficiency between DMNPC and the guanidinylating reagents N,N′-bis-Boc-1-pyrazole-1-carboxamidine (2) and N,N′-bis-Boc- N′-triflylguanidine (3).
Author(s): Castillo-Melendez JA, Golding BT
Publication type: Article
Publication status: Published
ISSN (print): 0039-7881
ISSN (electronic): 1437-210X
Publisher: Georg Thieme Verlag
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