Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska,
Dr Evelyn Jaros,
Emeritus Professor Robert Perry,
Emeritus Professor Elaine Perry
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The neuropathological substrates underlying the characteristic clinical phenotype of autism are unknown. Neuroimaging studies have identified a decrease in task-related activation in the dorsolateral prefrontal cortex in autism. In the current study, we have analysed the dorsolateral prefrontal cortex in two adult individuals with a clinical diagnosis of autism, using Niss1 staining and MAP2 immunohistochemistry. There was unchanged density of both neuronal and glial cell pools, although the autistic individuals had ill-defined neocortical cellular layers, substantially depleted MAP2 neuronal expression, and reduced dendrite numbers. Further studies on a larger number of individuals with autism are needed to establish the clinical relevance of the described changes, especially to determine whether the loss of dendritic markers is age associated or disease specific.
Author(s): Mukaetova-Ladinska EB, Arnold H, Jaros E, Perry R, Perry E
Publication type: Article
Publication status: Published
Journal: Neuropathology and Applied Neurobiology
Print publication date: 01/12/2004
ISSN (print): 0305-1846
ISSN (electronic): 1365-2990
PubMed id: 15541002
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