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Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication

Lookup NU author(s): Professor Ann Daly, Dr Santosh Gupta

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Abstract

Drug metabolism may be perturbed by genetically determined differences in the metabolic activity of cytochrome P450 enzymes. The authors encountered extensive bleeding in a patient receiving warfarin for anticoagulation after the introduction of celecoxib, an anti-inflammatory drug. As the CYP2C9 enzyme metabolises these drugs, it was determined whether variant alleles were responsible for altering warfarin handling. Genetic analysis established that the patient was a compound heterozygote with CYP2C9*2 and *3 variant alleles, which exhibit lower drug metabolising capacity and enhance susceptibility to drug toxicity.


Publication metadata

Author(s): Malhi H, Atac B, Daly AK, Gupta S

Publication type: Article

Publication status: Published

Journal: Postgraduate Medical Journal

Year: 2004

Volume: 80

Issue: 940

Pages: 107-109

Print publication date: 01/02/2004

ISSN (print): 0032-5473

ISSN (electronic): 1469-0756

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/pmj.2003.006478

DOI: 10.1136/pmj.2003.006478

PubMed id: 14970301


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