Lookup NU author(s): Professor Ann Daly,
Dr Santosh Gupta
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Drug metabolism may be perturbed by genetically determined differences in the metabolic activity of cytochrome P450 enzymes. The authors encountered extensive bleeding in a patient receiving warfarin for anticoagulation after the introduction of celecoxib, an anti-inflammatory drug. As the CYP2C9 enzyme metabolises these drugs, it was determined whether variant alleles were responsible for altering warfarin handling. Genetic analysis established that the patient was a compound heterozygote with CYP2C9*2 and *3 variant alleles, which exhibit lower drug metabolising capacity and enhance susceptibility to drug toxicity.
Author(s): Malhi H, Atac B, Daly AK, Gupta S
Publication type: Article
Publication status: Published
Journal: Postgraduate Medical Journal
Print publication date: 01/02/2004
ISSN (print): 0032-5473
ISSN (electronic): 1469-0756
Publisher: BMJ Group
PubMed id: 14970301
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