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Bicarbonate secretion: It takes two to tango

Lookup NU author(s): Dr Michael Gray

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Abstract

New research reveals a reciprocal regulation between the CFTR chloride channel, implicated in cystic fibrosis, and several members of the SLC26 family of chloride-bicarbonate exchangers. These findings provide new insights into the mechanism of epithelial bicarbonate and fluid transport and may lead to better treatments for cystic fibrosis and congenital chloride diarrhoeas.

Publication metadata

Author(s): Gray MA

Publication type: Article

Publication status: Published

Journal: Nature Cell Biology

Year: 2004

Volume: 6

Issue: 4

Pages: 292-294

Print publication date: 01/04/2004

ISSN (print): 1465-7392

ISSN (electronic): 1476-4679

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ncb0404-292

DOI: 10.1038/ncb0404-292

PubMed id: 15057243

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