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Messenger RNA stability in mitochondria: Different means to an end

Lookup NU author(s): Dr Richard Temperley, Professor Robert Lightowlers, Professor Zofia Chrzanowska-Lightowlers

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Abstract

Gene expression is regulated at many stages not merely at the level of transcription. Among the important post-transcriptional processes, RNA turnover has a crucial role. The stability of mRNA in the cytosol of eukarya is increased by the addition of a 3′ poly(A) extension. By contrast, this process mediates rapid RNA decay in prokarya. How is mRNA turnover regulated in mitochondria? Their monophyletic, α-proteobacterial origin predicts that polyadenylation will induce rapid decay by nucleases and associated factors that are similar to their bacterial ancestors. In this article, however, we report that the regulation of mitochondrial mRNA turnover in diverse species is surprisingly different.


Publication metadata

Author(s): Gagliardi D, Stepien PP, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: Trends in Genetics

Year: 2004

Volume: 20

Issue: 6

Pages: 260-267

ISSN (print): 0168-9525

ISSN (electronic): 1362-4555

Publisher: Elsevier Ltd.

URL: http://dx.doi.org/10.1016/j.tig.2004.04.006

DOI: 10.1016/j.tig.2004.04.006

PubMed id: 15145579


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