Lookup NU author(s): Dr Richard Temperley,
Professor Robert Lightowlers,
Professor Zofia Chrzanowska-Lightowlers
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Gene expression is regulated at many stages not merely at the level of transcription. Among the important post-transcriptional processes, RNA turnover has a crucial role. The stability of mRNA in the cytosol of eukarya is increased by the addition of a 3′ poly(A) extension. By contrast, this process mediates rapid RNA decay in prokarya. How is mRNA turnover regulated in mitochondria? Their monophyletic, α-proteobacterial origin predicts that polyadenylation will induce rapid decay by nucleases and associated factors that are similar to their bacterial ancestors. In this article, however, we report that the regulation of mitochondrial mRNA turnover in diverse species is surprisingly different.
Author(s): Gagliardi D, Stepien PP, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZMA
Publication type: Article
Publication status: Published
Journal: Trends in Genetics
ISSN (print): 0168-9525
ISSN (electronic): 1362-4555
Publisher: Elsevier Ltd.
PubMed id: 15145579
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