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Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14

Lookup NU author(s): Dr James Stach

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Abstract

The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified. © 2005 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Bringmann G, Lang G, Maksimenka K, Hamm A, Gulder TAM, Dieter A, Bull AT, Stach JEM, Kocher N, Muller WEG, Fiedler H-P

Publication type: Article

Publication status: Published

Journal: Phytochemistry

Year: 2005

Volume: 66

Issue: 11

Pages: 1366-1373

Print publication date: 01/06/2005

ISSN (print): 0031-9422

ISSN (electronic): 1873-3700

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.phytochem.2005.04.010

DOI: 10.1016/j.phytochem.2005.04.010

PubMed id: 15907962


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