Lookup NU author(s): Dr James Stach
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The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified. © 2005 Elsevier Ltd. All rights reserved.
Author(s): Bringmann G, Lang G, Maksimenka K, Hamm A, Gulder TAM, Dieter A, Bull AT, Stach JEM, Kocher N, Muller WEG, Fiedler H-P
Publication type: Article
Publication status: Published
Print publication date: 01/06/2005
ISSN (print): 0031-9422
ISSN (electronic): 1873-3700
PubMed id: 15907962
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