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Synthesis of highly substituted pyrrolidines via palladium catalysed formal [2+3] cycloaddition of 5-vinyloxazolidin-2-ones to activated alkenes

Lookup NU author(s): Dr Julian Knight, Dr Kirill Tchabanenko, Dr Paul Stoker, Dr Simon Harwood

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Abstract

Glycine-derived N-tosyl-5,5-divinyloxazolidin-2-one 10 undergoes a palladium catalysed decarboxylative ring-opening cyclization with strongly electron deficient alkylidenemalonate derivatives to give highly substituted pyrrolidines 14 containing two contiguous quaternary centres. © 2005 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Knight JG, Tchabanenko K, Stoker PA, Harwood SJ

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 2005

Volume: 46

Issue: 37

Pages: 6261-6264

Print publication date: 12/09/2005

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.tetlet.2005.07.053

DOI: 10.1016/j.tetlet.2005.07.053

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