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Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: A pilot study

Lookup NU author(s): Dr Stuart Watson, Jill Thompson, Emeritus Professor Nicol Ferrier, Professor Allan Young

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Abstract

Objective: To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder. Method: We examined HPA axis function in a pilot study of five patients with rapid-cycling bipolar disorder in both relapse and remission using the dexamethasone/corticotropin releasing hormone (dex/CRH) test. Results: The cortisol response to the dex/CRH test correlated significantly between the 2 tests (r = 0.997; p < 0.0005). Conclusion: The data suggests that the cortisol response to the dex/CRH test is stable over time and independent of mood state.

Publication metadata

Author(s): Watson S, Thompson JM, Malik N, Ferrier IN, Young AH

Publication type: Article

Publication status: Published

Journal: Australian and New Zealand Journal of Psychiatry

Year: 2005

Volume: 39

Issue: 4

Pages: 244-248

Print publication date: 01/04/2005

ISSN (print): 0004-8674

ISSN (electronic): 1440-1614

Publisher: Wiley

URL: .http:dx.doi.org/10.1111/j.1440-1614.2005.01560.x

DOI: 10.1111/j.1440-1614.2005.01560.x

PubMed id: 15777360

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